CSN1_HUMAN

Source: hRBCD ; ID: IPI00156282
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: GPS1 , COPS1, CSN1
Protein names and data: CSN1_HUMAN , COP9 signalosome complex subunit 1; SGN1; Signalosome subunit 1 , G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH Lenght: 491 a.a.
Mass: 55537 Da
fasta formatted sequence
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed.

Database cross-references

UniProt: Q13098
Ensembl: ENST00000306823
Ensembl: ENST00000355130
Ensembl: ENST00000392358
Ensembl: ENST00000578552
MIM: 601934
neXtProt: NX_Q13098
Antibodypedia: Q13098 (may not find the protein thus also not any antibody)
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