CSN2_HUMAN

Source: hRBCD ; ID: IPI00018813
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: COPS2 , CSN2, TRIP15
Protein names and data: CSN2_HUMAN , COP9 signalosome complex subunit 2; SGN2; Signalosome subunit 2 , Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 Lenght: 443 a.a.
Mass: 51597 Da
fasta formatted sequence
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Cellular location: Cytoplasm. Nucleus.

Database cross-references

UniProt: P61201
Ensembl: ENST00000299259
Ensembl: ENST00000388901
MIM: 604508
neXtProt: NX_P61201
Antibodypedia: P61201 (may not find the protein thus also not any antibody)
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