CSN6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: COPS6 , CSN6, HVIP
Protein names and data: CSN6_HUMAN , COP9 signalosome complex subunit 6; SGN6; Signalosome subunit 6 , JAB1-containing signalosome subunit 6; MOV34 homolog; Vpr-interacting protein; hVIP Lenght: 327 a.a.
Mass: 36163 Da
fasta formatted sequence
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.
Cellular location: Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Tissue specificity: Widely expressed.

Database cross-references

UniProt: Q7L5N1
Ensembl: ENST00000303904
MIM: 614729
neXtProt: NX_Q7L5N1
Antibodypedia: Q7L5N1 (may not find the protein thus also not any antibody)
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