CSN7A_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: COPS7A , CSN7A, DERP10
Protein names and data: CSN7A_HUMAN , COP9 signalosome complex subunit 7a; SGN7a; Signalosome subunit 7a , Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a Lenght: 275 a.a.
Mass: 30277 Da
fasta formatted sequence
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle.

Database cross-references

UniProt: Q9UBW8
Ensembl: ENST00000229251
Ensembl: ENST00000534877
Ensembl: ENST00000534947
Ensembl: ENST00000539735
Ensembl: ENST00000543155
neXtProt: NX_Q9UBW8
Antibodypedia: Q9UBW8 (may not find the protein thus also not any antibody)
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