CSN7B_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: COPS7B , CSN7B
Protein names and data: CSN7B_HUMAN , COP9 signalosome complex subunit 7b; SGN7b; Signalosome subunit 7b , JAB1-containing signalosome subunit 7b Lenght: 264 a.a.
Mass: 29622 Da
fasta formatted sequence
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular location: Cytoplasm. Nucleus.

Database cross-references

UniProt: Q9H9Q2
Ensembl: ENST00000350033
Ensembl: ENST00000373608
Ensembl: ENST00000409091
Ensembl: ENST00000410024
neXtProt: NX_Q9H9Q2
Antibodypedia: Q9H9Q2 (may not find the protein thus also not any antibody)
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