CTDS1_HUMAN

Source: PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CTDSP1 , NIF3, NLIIF, SCP1
Protein names and data: CTDS1_HUMAN , Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; 3.1.3.16 , Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1 Lenght: 261 a.a.
Mass: 29203 Da
fasta formatted sequence
Function: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Nucleus. Note=Colocalizes with RNA polymerase II.
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.

Genetic variants

Database cross-references

UniProt: Q9GZU7
Ensembl: ENST00000273062
Ensembl: ENST00000443891
MIM: 605323
neXtProt: NX_Q9GZU7
Antibodypedia: Q9GZU7 (may not find the protein thus also not any antibody)
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