RBCC Red Blood Cell Collection

CUED2_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CUEDC2 , C10orf66 , HOYS6
Protein names and data: CUED2_HUMAN , CUE domain-containing protein 2 Lenght: 287 a.a.
Mass: 32009 Da
fasta formatted sequence
Function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Disease: ( OMIM: 614142 ) Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Database cross-references

UniProt: Q9H467
Ensembl: ENST00000369937
MIM: 614142
neXtProt: NX_Q9H467
Antibodypedia: Q9H467 (may not find the protein thus also not any antibody)
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