CUL2_HUMAN

Source: hRBCD ; ID: IPI00014311
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CUL2
Protein names and data: CUL2_HUMAN , Cullin-2; CUL-2 Lenght: 745 a.a.
Mass: 86983 Da
fasta formatted sequence
Function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Pathway: Protein modification; protein ubiquitination.

Genetic variants

Database cross-references

UniProt: Q13617
Ensembl: ENST00000374748
Ensembl: ENST00000374749
Ensembl: ENST00000374751
Ensembl: ENST00000537177
MIM: 603135
neXtProt: NX_Q13617
Antibodypedia: Q13617 (may not find the protein thus also not any antibody)
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