CUL5_HUMAN

Source: hRBCD ; ID: IPI00216003
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CUL5 , VACM1
Protein names and data: CUL5_HUMAN , Cullin-5; CUL-5 , Vasopressin-activated calcium-mobilizing receptor 1; VACM-1 Lenght: 780 a.a.
Mass: 90955 Da
fasta formatted sequence
Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Pathway: Protein modification; protein ubiquitination.

Database cross-references

UniProt: Q93034
Ensembl: ENST00000393094
Ensembl: ENST00000531427
MIM: 601741
neXtProt: NX_Q93034
Antibodypedia: Q93034 (may not find the protein thus also not any antibody)
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