Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CYBB , NOX2
Protein names and data: CY24B_HUMAN , Cytochrome b-245 heavy chain; 1.-.-.- , CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome Lenght: 570 a.a.
Mass: 65336 Da
fasta formatted sequence

Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Cellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Detected in neutrophils (at protein level).

Genetic variants

Database cross-references

UniProt: P04839
Ensembl: ENST00000378588
Ensembl: ENST00000596392
MIM: 300481
MIM: 300645
MIM: 306400
neXtProt: NX_P04839
Antibodypedia: P04839 (may not find the protein thus also not any antibody)
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