CYBR1_HUMAN

Source: hRBCD ; ID: IPI00432050
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CYBRD1 , DCYTB, FRRS3
Protein names and data: CYBR1_HUMAN , Cytochrome b reductase 1; 1.-.-.- , Duodenal cytochrome b; Ferric-chelate reductase 3 Lenght: 286 a.a.
Mass: 31641 Da
fasta formatted sequence
Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.
Cellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.

Genetic variants

Genetic variations in CYBRD1 may act as modifier of iron overload expression and account for the variance observed in serum ferritin levels in patients with hereditary hemochromatosis.

Database cross-references

UniProt: Q53TN4
Ensembl: ENST00000321348
Ensembl: ENST00000375252
Ensembl: ENST00000409484
MIM: 605745
neXtProt: NX_Q53TN4
Antibodypedia: Q53TN4 (may not find the protein thus also not any antibody)
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