Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CYCS , CYC
Protein names and data: CYC_HUMAN , Cytochrome c Lenght: 105 a.a.
Mass: 11749 Da
fasta formatted sequence

Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Cellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Genetic variants

Database cross-references

UniProt: P99999
Ensembl: ENST00000305786
Ensembl: ENST00000409409
Ensembl: ENST00000409764
MIM: 123970
MIM: 612004
neXtProt: NX_P99999
Antibodypedia: P99999 (may not find the protein thus also not any antibody)
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