CYFP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CYFIP1 , KIAA0068
Protein names and data: CYFP1_HUMAN , Cytoplasmic FMR1-interacting protein 1 , Specifically Rac1-associated protein 1; Sra-1; p140sra-1 Lenght: 1253 a.a.
Mass: 145182 Da
fasta formatted sequence
Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
Cellular location: Cytoplasm, perinuclear region (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity).

Genetic variants

Database cross-references

UniProt: Q7L576
Ensembl: ENST00000313077
Ensembl: ENST00000435939
Ensembl: ENST00000560848
MIM: 606322
neXtProt: NX_Q7L576
Antibodypedia: Q7L576 (may not find the protein thus also not any antibody)
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