DBNL_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DBNL , CMAP, SH3P7 , PP5423
Protein names and data: DBNL_HUMAN , Drebrin-like protein , Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7 Lenght: 430 a.a.
Mass: 48207 Da
fasta formatted sequence
Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Cellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasm, cytosol (By similarity). Cell junction, synapse (By similarity). Cell projection (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, clathrin- coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, podosome (By similarity). Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity).

Database cross-references

UniProt: Q9UJU6
Ensembl: ENST00000448521
Ensembl: ENST00000468694
Ensembl: ENST00000494774
MIM: 610106
neXtProt: NX_Q9UJU6
Antibodypedia: Q9UJU6 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.