DCAF7_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DCAF7 , HAN11, WDR68
Protein names and data: DCAF7_HUMAN , DDB1- and CUL4-associated factor 7 , WD repeat-containing protein 68; WD repeat-containing protein An11 homolog Lenght: 342 a.a.
Mass: 38926 Da
fasta formatted sequence
Function: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.

Database cross-references

UniProt: P61962
Ensembl: ENST00000310827
MIM: 605973
neXtProt: NX_P61962
Antibodypedia: P61962 (may not find the protein thus also not any antibody)
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