Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: DCD , AIDD, DSEP
Protein names and data: DCD_HUMAN , Dermcidin; 3.4.-.- , Preproteolysin; Survival-promoting peptide; DCD-1; Flags: Precursor Lenght: 110 a.a.
Mass: 11284 Da
fasta formatted sequence

Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Cellular location: Secreted.
Tissue specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Database cross-references

UniProt: P81605
Ensembl: ENST00000293371
Ensembl: ENST00000456047
Ensembl: ENST00000546807
MIM: 606634
neXtProt: NX_P81605
Antibodypedia: P81605 (may not find the protein thus also not any antibody)
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