DCNL1_HUMAN

Source: hRBCD ; ID: IPI00291893
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: DCUN1D1 , DCUN1L1, RP42, SCCRO
Protein names and data: DCNL1_HUMAN , DCN1-like protein 1 , DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene Lenght: 259 a.a.
Mass: 30124 Da
fasta formatted sequence
Function: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
Tissue specificity: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Database cross-references

UniProt: Q96GG9
Ensembl: ENST00000292782
MIM: 605905
neXtProt: NX_Q96GG9
Antibodypedia: Q96GG9 (may not find the protein thus also not any antibody)
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