DCTN4_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: DCTN4
Protein names and data: DCTN4_HUMAN , Dynactin subunit 4; Dyn4 , Dynactin subunit p62 Lenght: 460 a.a.
Mass: 52337 Da
fasta formatted sequence
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Cellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.

Genetic variants

Database cross-references

UniProt: Q9UJW0
Ensembl: ENST00000424236
Ensembl: ENST00000446090
Ensembl: ENST00000447998
MIM: 614758
neXtProt: NX_Q9UJW0
Antibodypedia: Q9UJW0 (may not find the protein thus also not any antibody)
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