DCXR_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DCXR
Protein names and data: DCXR_HUMAN , L-xylulose reductase; XR; 1.1.1.10 , Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H Lenght: 244 a.a.
Mass: 25913 Da
fasta formatted sequence
Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Catalytic activity: Xylitol + NADP(+) = L-xylulose + NADPH.
Disease:
Cellular location: Membrane; Peripheral membrane protein (By similarity). Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity).
Tissue specificity: Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.

Database cross-references

UniProt: Q7Z4W1
Ensembl: ENST00000306869
MIM: 608347
neXtProt: NX_Q7Z4W1
Antibodypedia: Q7Z4W1 (may not find the protein thus also not any antibody)
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