DDAH2_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DDAH2 , DDAH, G6A, NG30
Protein names and data: DDAH2_HUMAN , N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; DDAH-2; Dimethylarginine dimethylaminohydrolase 2; 3.5.3.18 , DDAHII; Dimethylargininase-2; Protein G6a; S-phase protein Lenght: 285 a.a.
Mass: 29644 Da
fasta formatted sequence
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Catalytic activity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
Cellular location: Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
Tissue specificity: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.

Database cross-references

UniProt: O95865
Ensembl: ENST00000375787
Ensembl: ENST00000375789
Ensembl: ENST00000375792
Ensembl: ENST00000383409
Ensembl: ENST00000400062
Ensembl: ENST00000400063
Ensembl: ENST00000411456
Ensembl: ENST00000413532
Ensembl: ENST00000413655
Ensembl: ENST00000414455
Ensembl: ENST00000424790
Ensembl: ENST00000426149
Ensembl: ENST00000427126
Ensembl: ENST00000430482
Ensembl: ENST00000434464
Ensembl: ENST00000437889
Ensembl: ENST00000443533
Ensembl: ENST00000444699
Ensembl: ENST00000447101
Ensembl: ENST00000451411
Ensembl: ENST00000454138
MIM: 604744
neXtProt: NX_O95865
Antibodypedia: O95865 (may not find the protein thus also not any antibody)
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