Source: hRBCD ; ID: IPI00216633
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: DMTN , DMT, EPB49
Protein names and data: DEMA_HUMAN , Dematin , Dematin actin-binding protein; Erythrocyte membrane protein band 4.9 Lenght: 405 a.a.
Mass: 45514 Da
fasta formatted sequence

Function: Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Cellular location: Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region (By similarity). Cytoplasm, cytoskeleton. Cell membrane. Membrane (By similarity). Endomembrane system. Cell projection (By similarity). Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuol in malaria- infected erythrocytes at late stages of plasmodium berghei or falciparum development.
Tissue specificity: Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.

Database cross-references

UniProt: Q08495
Ensembl: ENST00000265800
Ensembl: ENST00000358242
Ensembl: ENST00000381470
Ensembl: ENST00000415253
Ensembl: ENST00000432128
Ensembl: ENST00000443491
Ensembl: ENST00000519907
Ensembl: ENST00000523266
Ensembl: ENST00000523782
MIM: 125305
neXtProt: NX_Q08495
Antibodypedia: Q08495 (may not find the protein thus also not any antibody)
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