Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: DERL1 , DER1 , UNQ243/PRO276
Protein names and data: DERL1_HUMAN , Derlin-1 , Degradation in endoplasmic reticulum protein 1; DERtrin-1; Der1-like protein 1 Lenght: 251 a.a.
Mass: 28801 Da
fasta formatted sequence

Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9BUN8
Ensembl: ENST00000259512
Ensembl: ENST00000405944
MIM: 608813
neXtProt: NX_Q9BUN8
Antibodypedia: Q9BUN8 (may not find the protein thus also not any antibody)
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