DHSO_HUMAN

Source: hRBCD ; ID: IPI00216057
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: SORD
Protein names and data: DHSO_HUMAN , Sorbitol dehydrogenase; 1.1.1.14 , L-iditol 2-dehydrogenase Lenght: 357 a.a.
Mass: 38325 Da
fasta formatted sequence
Function: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).
Catalytic activity: L-iditol + NAD(+) = L-sorbose + NADH.
Cellular location: Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface (By similarity).
Tissue specificity: Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).

Genetic variants

Database cross-references

UniProt: Q00796
Ensembl: ENST00000267814
MIM: 182500
neXtProt: NX_Q00796
Antibodypedia: Q00796 (may not find the protein thus also not any antibody)
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