DNJB6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DNAJB6 , HSJ2, MRJ, MSJ1
Protein names and data: DNJB6_HUMAN , DnaJ homolog subfamily B member 6 , HHDJ1; Heat shock protein J2; HSJ-2; MRJ; MSJ-1 Lenght: 326 a.a.
Mass: 36087 Da
fasta formatted sequence
Function: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Disease:
Cellular location: Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Tissue specificity: Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.

Genetic variants

Database cross-references

UniProt: O75190
Ensembl: ENST00000262177
Ensembl: ENST00000429029
MIM: 603511
MIM: 611332
neXtProt: NX_O75190
Antibodypedia: O75190 (may not find the protein thus also not any antibody)
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