DNJC2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DNAJC2 , MPHOSPH11, MPP11, ZRF1
Protein names and data: DNJC2_HUMAN , DnaJ homolog subfamily C member 2 , M-phase phosphoprotein 11; Zuotin-related factor 1 Lenght: 621 a.a.
Mass: 71996 Da
fasta formatted sequence
Function: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
Cellular location: Nucleus. Cytoplasm, cytosol.
Tissue specificity: Widely expressed.

Database cross-references

UniProt: Q99543
Ensembl: ENST00000249270
Ensembl: ENST00000379263
MIM: 605502
neXtProt: NX_Q99543
Antibodypedia: Q99543 (may not find the protein thus also not any antibody)
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