DPH3_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DPH3 , DESR1, ZCSL2
Protein names and data: DPH3_HUMAN , DPH3 homolog , CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1 Lenght: 82 a.a.
Mass: 9240 Da
fasta formatted sequence
Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta) (By similarity). Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.
Pathway: Protein modification; peptidyl-diphthamide biosynthesis.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung.

Database cross-references

UniProt: Q96FX2
Ensembl: ENST00000383775
Ensembl: ENST00000488423
MIM: 608959
neXtProt: NX_Q96FX2
Antibodypedia: Q96FX2 (may not find the protein thus also not any antibody)
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