ECP_HUMAN

Source: PM23856902
BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: RNASE3 , ECP, RNS3
Protein names and data: ECP_HUMAN , Eosinophil cationic protein; ECP; 3.1.27.- , Ribonuclease 3; RNase 3; Flags: Precursor Lenght: 160 a.a.
Mass: 18385 Da
fasta formatted sequence
Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Cellular location: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Genetic variants

Database cross-references

UniProt: P12724
Ensembl: ENST00000304639
MIM: 131398
neXtProt: NX_P12724
Antibodypedia: P12724 (may not find the protein thus also not any antibody)
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