EF1A1_HUMAN

Source: hRBCD ; ID: IPI00025447
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: EEF1A1 , EEF1A, EF1A, LENG7
Protein names and data: EF1A1_HUMAN , Elongation factor 1-alpha 1; EF-1-alpha-1 , Elongation factor Tu; EF-Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1; Leukocyte receptor cluster member 7 Lenght: 462 a.a.
Mass: 50141 Da
fasta formatted sequence
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Cellular location: Cytoplasm. Nucleus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery.
Tissue specificity: Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.

Database cross-references

UniProt: P68104
Ensembl: ENST00000309268
Ensembl: ENST00000316292
Ensembl: ENST00000331523
MIM: 130590
neXtProt: NX_P68104
Antibodypedia: P68104 (may not find the protein thus also not any antibody)
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