EFNB1_HUMAN

Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: EFNB1 , EFL3, EPLG2, LERK2
Protein names and data: EFNB1_HUMAN , Ephrin-B1 , EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; Flags: Precursor Lenght: 346 a.a.
Mass: 38007 Da
fasta formatted sequence

Function: Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Disease:
Cellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.

Genetic variants

Database cross-references

UniProt: P98172
Ensembl: ENST00000204961
MIM: 300035
MIM: 304110
neXtProt: NX_P98172
Antibodypedia: P98172 (may not find the protein thus also not any antibody)
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