Source: PM19886704
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: ENG , END
Protein names and data: EGLN_HUMAN , Endoglin , CD105; Flags: Precursor Lenght: 658 a.a.
Mass: 70578 Da
fasta formatted sequence

Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Cellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow.

Genetic variants

Database cross-references

UniProt: P17813
Ensembl: ENST00000344849
Ensembl: ENST00000373203
MIM: 131195
MIM: 187300
neXtProt: NX_P17813
Antibodypedia: P17813 (may not find the protein thus also not any antibody)
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