EIF2D_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF2D , HCA56, LGTN
Protein names and data: EIF2D_HUMAN , Eukaryotic translation initiation factor 2D; eIF2d , Hepatocellular carcinoma-associated antigen 56; Ligatin Lenght: 584 a.a.
Mass: 64706 Da
fasta formatted sequence
Function: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P- site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: P41214
Ensembl: ENST00000271764
Ensembl: ENST00000367114
Ensembl: ENST00000580424
Ensembl: ENST00000585127
MIM: 613709
neXtProt: NX_P41214
Antibodypedia: P41214 (may not find the protein thus also not any antibody)
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