EIF3C_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF3C , EIF3S8
Protein names and data: EIF3C_HUMAN , Eukaryotic translation initiation factor 3 subunit C; eIF3c , Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110 Lenght: 913 a.a.
Mass: 105344 Da
fasta formatted sequence
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Cellular location: Cytoplasm (By similarity).

Database cross-references

UniProt: Q99613
Ensembl: ENST00000331666
Ensembl: ENST00000395587
Ensembl: ENST00000566501
Ensembl: ENST00000566866
MIM: 603916
neXtProt: NX_Q99613
Antibodypedia: Q99613 (may not find the protein thus also not any antibody)
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