EIF3F_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF3F , EIF3S5
Protein names and data: EIF3F_HUMAN , Eukaryotic translation initiation factor 3 subunit F; eIF3f , Deubiquitinating enzyme eIF3f; 3.4.19.12; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47 Lenght: 357 a.a.
Mass: 37564 Da
fasta formatted sequence
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm (By similarity).

Genetic variants

Database cross-references

UniProt: O00303
Ensembl: ENST00000309828
Ensembl: ENST00000533626
MIM: 603914
neXtProt: NX_O00303
Antibodypedia: O00303 (may not find the protein thus also not any antibody)
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