EIF3K_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF3K , EIF3S12 , ARG134, HSPC029, MSTP001, PTD001
Protein names and data: EIF3K_HUMAN , Eukaryotic translation initiation factor 3 subunit K; eIF3k , Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; PLAC-24; eIF-3 p25; eIF-3 p28 Lenght: 218 a.a.
Mass: 25060 Da
fasta formatted sequence
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Cellular location: Nucleus. Cytoplasm.
Tissue specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney.

Database cross-references

UniProt: Q9UBQ5
Ensembl: ENST00000248342
MIM: 609596
neXtProt: NX_Q9UBQ5
Antibodypedia: Q9UBQ5 (may not find the protein thus also not any antibody)
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