ELOB_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TCEB2
Protein names and data: ELOB_HUMAN , Transcription elongation factor B polypeptide 2 , Elongin 18 kDa subunit; Elongin-B; EloB; RNA polymerase II transcription factor SIII subunit B; SIII p18 Lenght: 118 a.a.
Mass: 13133 Da
fasta formatted sequence
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Nucleus (Probable).

Database cross-references

UniProt: Q15370
Ensembl: ENST00000262306
Ensembl: ENST00000409906
MIM: 600787
neXtProt: NX_Q15370
Antibodypedia: Q15370 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.