ELOC_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TCEB1
Protein names and data: ELOC_HUMAN , Transcription elongation factor B polypeptide 1 , Elongin 15 kDa subunit; Elongin-C; EloC; RNA polymerase II transcription factor SIII subunit C; SIII p15 Lenght: 112 a.a.
Mass: 12473 Da
fasta formatted sequence
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Cellular location: Nucleus (Probable).
Tissue specificity: Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3.

Database cross-references

UniProt: Q15369
Ensembl: ENST00000284811
Ensembl: ENST00000518127
Ensembl: ENST00000519487
Ensembl: ENST00000520210
Ensembl: ENST00000520242
Ensembl: ENST00000522337
Ensembl: ENST00000523815
MIM: 600788
neXtProt: NX_Q15369
Antibodypedia: Q15369 (may not find the protein thus also not any antibody)
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