ENOA_HUMAN

Source: hRBCD ; ID: IPI00215736
PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ENO1 , ENO1L1, MBPB1, MPB1
Protein names and data: ENOA_HUMAN , Alpha-enolase; 4.2.1.11 , 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein Lenght: 434 a.a.
Mass: 47169 Da
fasta formatted sequence
Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
Pathway: Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5.
Cellular location: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line. Isoform MBP-1: Nucleus.
Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Genetic variants

Database cross-references

UniProt: P06733
Ensembl: ENST00000234590
MIM: 172430
neXtProt: NX_P06733
Antibodypedia: P06733 (may not find the protein thus also not any antibody)
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