ENOG_HUMAN
Source: hRBCD ; ID: IPI00216171PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ENO2
Protein names and data: ENOG_HUMAN , Gamma-enolase; 4.2.1.11 , 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE Lenght: 434 a.a.
Mass: 47269 Da
fasta formatted sequence
Function: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
Pathway: Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5.
Cellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity).
Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
Genetic variants
Database cross-references
UniProt: P09104Ensembl: ENST00000229277
Ensembl: ENST00000535366
Ensembl: ENST00000541477
Ensembl: ENST00000594987
Ensembl: ENST00000596089
Ensembl: ENST00000601485
MIM: 131360
neXtProt: NX_P09104
Antibodypedia: P09104 (may not find the protein thus also not any antibody)
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