EPN1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EPN1
Protein names and data: EPN1_HUMAN , Epsin-1 , EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1 Lenght: 576 a.a.
Mass: 60293 Da
fasta formatted sequence
Function: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Cellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).

Database cross-references

UniProt: Q9Y6I3
Ensembl: ENST00000085079
Ensembl: ENST00000270460
Ensembl: ENST00000411543
MIM: 607262
neXtProt: NX_Q9Y6I3
Antibodypedia: Q9Y6I3 (may not find the protein thus also not any antibody)
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