EPS15_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: EPS15 , AF1P
Protein names and data: EPS15_HUMAN , Epidermal growth factor receptor substrate 15; Protein Eps15 , Protein AF-1p Lenght: 896 a.a.
Mass: 98656 Da
fasta formatted sequence
Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Disease:
Cellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Isoform 2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: P42566
Ensembl: ENST00000371733
MIM: 600051
neXtProt: NX_P42566
Antibodypedia: P42566 (may not find the protein thus also not any antibody)
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