Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ERAP1 , APPILS, ARTS1, KIAA0525 , UNQ584/PRO1154
Protein names and data: ERAP1_HUMAN , Endoplasmic reticulum aminopeptidase 1; 3.4.11.- , ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator Lenght: 941 a.a.
Mass: 107235 Da
fasta formatted sequence

Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Catalytic activity: Release of an N-terminal amino acid, Xaa-|- Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Met, Cys and Phe.
Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable).
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9NZ08
Ensembl: ENST00000296754
Ensembl: ENST00000443439
MIM: 606832
neXtProt: NX_Q9NZ08
Antibodypedia: Q9NZ08 (may not find the protein thus also not any antibody)
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