ERRFI_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ERRFI1 , MIG6
Protein names and data: ERRFI_HUMAN , ERBB receptor feedback inhibitor 1 , Mitogen-inducible gene 6 protein; MIG-6 Lenght: 462 a.a.
Mass: 50560 Da
fasta formatted sequence
Function: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Cellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus (By similarity). Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).

Genetic variants

Database cross-references

UniProt: Q9UJM3
Ensembl: ENST00000377482
MIM: 608069
neXtProt: NX_Q9UJM3
Antibodypedia: Q9UJM3 (may not find the protein thus also not any antibody)
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