FADD_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: FADD , MORT1 , GIG3
Protein names and data: FADD_HUMAN , Protein FADD , FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity Lenght: 208 a.a.
Mass: 23279 Da
fasta formatted sequence

Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Disease:
Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Genetic variants

Database cross-references

UniProt: Q13158
Ensembl: ENST00000301838
MIM: 602457
MIM: 613759
neXtProt: NX_Q13158
Antibodypedia: Q13158 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.