FAS_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FASN , FAS
Protein names and data: FAS_HUMAN , Fatty acid synthase; 2.3.1.85; [Acyl-carrier-protein] S-acetyltransferase; 2.3.1.38; [Acyl-carrier-protein] S-malonyltransferase; 2.3.1.39; 3-oxoacyl-[acyl-carrier-protein] synthase; 2.3.1.41; 3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.100; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 4.2.1.59; Enoyl-[acyl-carrier-protein] reductase; 1.3.1.39; Oleoyl-[acyl-carrier-protein] hydrolase; 3.1.2.14 Lenght: 2511 a.a.
Mass: 273427 Da
fasta formatted sequence
Function: Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Catalytic activity: Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+). Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]. Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]. Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH. Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.
Cellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver.

Genetic variants

Database cross-references

UniProt: P49327
Ensembl: ENST00000306749
MIM: 600212
neXtProt: NX_P49327
Antibodypedia: P49327 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.