FBP1L_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FNBP1L , C1orf39, TOCA1
Protein names and data: FBP1L_HUMAN , Formin-binding protein 1-like , Transducer of Cdc42-dependent actin assembly protein 1; Toca-1 Lenght: 605 a.a.
Mass: 69977 Da
fasta formatted sequence
Function: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
Cellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasmic vesicle (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

Database cross-references

UniProt: Q5T0N5
Ensembl: ENST00000260506
Ensembl: ENST00000370253
Ensembl: ENST00000370256
MIM: 608848
neXtProt: NX_Q5T0N5
Antibodypedia: Q5T0N5 (may not find the protein thus also not any antibody)
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