RBCC Red Blood Cell Collection

FBX4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FBXO4 , FBX4
Protein names and data: FBX4_HUMAN , F-box only protein 4 Lenght: 387 a.a.
Mass: 44136 Da
fasta formatted sequence
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm (By similarity).

Genetic variants

8 - 8 S -> R (in esophagus cancer samples; dbSNP:rs2231917). VAR_063500 2231917
12 - 12 S -> L (in esophagus cancer sample; impairs homodimerization and reduces ubiquitin ligase activity). VAR_063501
13 - 13 P -> S (in esophagus cancer sample). VAR_063502
23 - 23 L -> Q (in esophagus cancer samples). VAR_063503
76 - 76 P -> T (in esophagus cancer samples; impairs interaction with SKP1). VAR_063504

Database cross-references

UniProt: Q9UKT5
Ensembl: ENST00000281623
Ensembl: ENST00000296812
MIM: 609090
neXtProt: NX_Q9UKT5
Antibodypedia: Q9UKT5 (may not find the protein thus also not any antibody)
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