FCHO2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FCHO2
Protein names and data: FCHO2_HUMAN , FCH domain only protein 2 Lenght: 810 a.a.
Mass: 88924 Da
fasta formatted sequence
Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Cellular location: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity).

Genetic variants

Database cross-references

UniProt: Q0JRZ9
Ensembl: ENST00000430046
Ensembl: ENST00000512348
MIM: 613438
neXtProt: NX_Q0JRZ9
Antibodypedia: Q0JRZ9 (may not find the protein thus also not any antibody)
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