RBCC Red Blood Cell Collection

FCN3_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FCN3 , FCNH, HAKA1
Protein names and data: FCN3_HUMAN , Ficolin-3 , Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen; Flags: Precursor Lenght: 299 a.a.
Mass: 32903 Da
fasta formatted sequence
Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
Disease: ( OMIM: 604973 613860 ) Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cellular location: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.

Database cross-references

UniProt: O75636
Ensembl: ENST00000270879
Ensembl: ENST00000354982
MIM: 604973
MIM: 613860
neXtProt: NX_O75636
Antibodypedia: O75636 (may not find the protein thus also not any antibody)
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