FKB1A_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FKBP1A , FKBP1, FKBP12
Protein names and data: FKB1A_HUMAN , Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; 5.2.1.8 , 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase Lenght: 108 a.a.
Mass: 11951 Da
fasta formatted sequence
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Cytoplasm.

Database cross-references

UniProt: P62942
Ensembl: ENST00000381719
Ensembl: ENST00000400137
MIM: 186945
neXtProt: NX_P62942
Antibodypedia: P62942 (may not find the protein thus also not any antibody)
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