FKBP4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FKBP4 , FKBP52
Protein names and data: FKBP4_HUMAN , Peptidyl-prolyl cis-trans isomerase FKBP4; PPIase FKBP4; 5.2.1.8 , 51 kDa FK506-binding protein; FKBP51; 52 kDa FK506-binding protein; 52 kDa FKBP; FKBP-52; 59 kDa immunophilin; p59; FK506-binding protein 4; FKBP-4; FKBP59; HSP-binding immunophilin; HBI; Immunophilin FKBP52; Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed Lenght: 459 a.a.
Mass: 51805 Da
fasta formatted sequence
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Cytoplasm, cytosol (By similarity). Mitochondrion. Nucleus. Cytoplasm, cytoskeleton (By similarity). Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: Q02790
Ensembl: ENST00000001008
MIM: 600611
neXtProt: NX_Q02790
Antibodypedia: Q02790 (may not find the protein thus also not any antibody)
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